The λ model suggests that detailed kinematics arise from changes in control variables and need not be explicitly planned. However, we have shown that when moving a grasped object, grip force is precisely modulated in phase with acceleration-dependent inertial load. This suggests that the motor system can predict detailed kinematics. This prediction may be based on a forward model of the dynamics of the loaded limb.

Bringing about desirable collisions (making interceptions) and avoiding unwanted collisions are critically important sensorimotor skills, which appear to require us to estimate the time remaining before collision occurs (time-to-collision). Until recently the theoretical approach to understanding time-to-collision estimation has been dominated by the tau-hypothesis, which has its origins in J.J. Gibson’s ecological approach to perception. The hypothesis proposes that a quantity (tau), present in the visual stimulus, provides the necessary time-to-collision information. Empirical results and formal analyses have now accumulated to (...) demonstrate conclusively that the tau-hypothesis is false. This article describes an alternative approach that is based on recent data showing that the information used in judging time-to-collision is task- and situation-dependent, is of many different origins (of which tau is just one) and is influenced by the information-processing constraints of the nervous system. (shrink)

This paper examines two puzzles of indeterminacy. The first puzzle concerns the hypothesis that there is a unified phenomenon of indeterminacy. How are we to reconcile this with the apparent diversity of reactions that indeterminacy prompts? The second puzzle focuses narrowly on borderline cases of vague predicates. How are we to account for the lack of theoretical consensus about what the proper reaction to borderline cases is? I suggest (building on work by Maudlin) that the characteristic feature of indeterminacy is (...) alethic normative silence, and use this to explain both plurality and lack of consensus. (shrink)

In a recent article, C. H. Kahn addresses an ‘old scholarly myth’, namely the idea that Book I of the Republic began life as an earlier, independent dialogue and was subsequently adapted to serve as a prelude to the much longer work that we know. The case for this hypothesis rests both on stylometric considerations and on the many ‘Socratic’ features that Book I, unlike the rest of the Republic, shares with Plato's earlier works. Having disposed of the positive arguments (...) in favour of the ‘myth’, Kahn turns to the contrary—and in his view overwhelming—evidence that Book I was composed from the start as an integral part of the longer Republic. He catalogues 12 passages in Book I, accounting for roughly half its length, whose full significance will, he argues, only emerge if they are seen as instances of prolepsis, deliberate anticipations of what is to come in later books. (shrink)

This paper outlines Lewis’s favoured foundational account of linguistic representation, and outlines and briefly evaluates variations and modifications. Section 1 gives an opinionated exegesis of Lewis’ work on the foundations of reference—his interpretationism. I look at the way that the metaphysical distinction between natural and non-natural properties came to play a central role in his thinking about language. Lewis’s own deployment of this notion has implausible commitments, so in section 2 I consider variations and alternatives. Section 3 briefly considers a (...) buck-passing strategy involving fine-grained linguistic conventions. (shrink)

A report by the Nuffield Council on Bioethics, contrary to the Declaration of Helsinki, permits most important research initiatives in developing countries.The Ethics of Research Related to Health Care in Developing Countries by the Nuffield Council on Bioethics makes a number of innovative recommendations that depart from codes such as the Declaration of Helsinki. It recommends that standards of care might be relativised to the standard of that nation. It recommends that very good reasons need to be given for not (...) giving post-trial access to medications but recognises that there may be justifiable instances of this. It is the view of the authors that these and other recommendations of the report are sensible pieces of advice given the complexities of the developing world. (shrink)

From all points of the political compass, from widely different groups, have come indignant outcries against the trade in human organs from live vendors. Opponents contend that such practices constitute a morally outrageous and gross exploitation of the poor, inherently coercive and obviously intolerable in any civilized society. This article examines the arguments typically offered in defense of these claims, and finds serious problems with all of them. The prohibition of organ sales is derived not from the principles and argument (...) usually invoked in support of prohibition, but rather, from strong feelings of repugnance which exert an invisible but powerful influence on the debate, distorting the arguments [and working] to the detriment of the [very] people most in need of protection. (shrink)

This study investigated the performance of boys with psychopathic tendencies and comparison boys, aged 9 to 17 years, on two tasks believed to be sensitive to amygdala and orbitofrontal cortex func- tioning. Fifty-one boys were divided into two groups according to the Psychopathy Screening Device (PSD, P. J. Frick & R. D. Hare, in press) and presented with two tasks. The tasks were the gambling task (A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994) and the Intradimensional/ (...) Extradimensional (ID/ED) shift task (R. Dias, T. W. Robbins, & A. C. Roberts, 1996). The boys with psychopathic tendencies showed impaired performance on the gambling task. However, there were no group differences on the ID/ED task either for response reversal or extradimensional set shifting. The implications of these results for models of psychopathy are discussed. (shrink)

The application of Gödel’s theorem to the problem of minds and machines is difficult. Paul Benacerraf makes the entirely valid ‘Duhemian’ point that the argument is not, and cannot be, a purely mathematical one, but needs some philosophical premisses to be able to yield any philosophical conclusions. Moreover, the philosophical premisses are of very different kinds. Some are concerned with what is essential to being a machine—these are typically intricate, but definite, easily formalised by the mathematician, but unintelligible to the (...) layman: others attempt to capture what is essential to being a mind, a person or a self—these are typically intuitive, but vague; resistant to exact definition by the logician, but, none the less, widely used and well understood. Gödel’s theorem itself, like many other truths, can be taken either way: it can be taken as a formal proof sequence yielding certain syntactical results about a certain class of formal systems, but it can also be taken as giving us a certain type or style of argument, which we can understand, and, once having got the hang of it, adapt and apply in innumerable different circumstances. In my dispute with the mechanist, I take Gödel’s argument both ways: I first take it as an argument which the mechanist, even according to his own mechanist principles, must accept as scoring some point against his favourite machine; and then I hope that the mechanist, as a man, will see that he can do better and that this sort of argument will always apply against any form of mechanism he espouses. (shrink)

Equality is the great political issue of our time. Liberty is forgotten: Fraternity never did engage our passions: the maintenance of Law and Order is at a discount: Natural Rights and Natural Justice are outmoded shibboleths. But Equality—there men have something to die for, kill for, agitate about, be miserable about. The demand for Equality obsesses all our political thought. We are not sure what it is—indeed, as I shall show later, we are necessarily not sure what it is—but we (...) are sure that whatever it is, we want it: and while we are prepared to look on frustration, injustice or violence with tolerance, as part of the natural order of things, we will work ourselves up into paroxysms of righteous indignation at the bare mention of Inequality. (shrink)

The purpose of this essay is to stimulate academic discussion about the ethical justification of using human primordial stem cells for tissue transplantation, cell replacement, and gene therapy. There are intriguing alternatives to using embryos obtained from elective abortions and in vitro fertilisation to reconstitute damaged or dysfunctional human organs. These include the expansion and transplantation of latent adult progenitor cells.

While the UK Home Office’s proposals to preventively detain people with what it has called dangerous severe personality disorder have been subjected to debate and criticism the deeply troubling jurisprudential issues in these proposals have not yet entered into public debate in a way that their seriousness deserves.1 It is good that a commentator as well known as Professor Szasz is speaking out on this issue.Professor Szasz focuses upon a crucial question by calling into question the medicalisation of terms like (...) dangerousness and mental illness.2 There is a great temptation for legislators and the public to treat these terms as if they are purely scientific terms and to think of risk assessment as a precise science. I don’t share Professor’s Szasz’s worry about how psychiatry is using these terms but I think there are some important questions about how these concepts function in the public sphere.This issue is important enough to justify the use of some rhetorical claims because such claims can serve to bring out what are neglected and important issues. In raising the following objections I am not attempting to refute the message that is in Szasz’s article or to say that he is not making an important point but rather to attempt to sharpen the issues and to suggest ways that we can respond to Professor Szasz’s challenge.Psychiatry has progressed in a number of ways since Professor Szasz wrote The Myth of Mental Illness.3 The science is much better, we have much better medications, and psychiatrists are acutely aware of the tension between treating their patient and their obligations to the public interest.So when Professor Szasz says: “Psychiatrists offer to relieve the disturbed person of the burden of coping …. (shrink)

Justice has always been regarded as one of the fundamental political virtues. No association of human individuals could subsist, says Hume, “were no regard paid to the laws of equity and justice”, and nearly every thinker who has turned to consider human society, has reached the same conclusion. Yet we are not at all clear what justice is, nor why it is so important. There are many other ideals which a society may cherish, and often reformers have felt impatient of (...) having to compromise their aims merely for the sake of justice, and have not seen why the claims of justice should in any way override other political goods. I shall try to show why justice is, along with liberty, a peculiarly fundamental ideal, which is not merely co-ordinate with other ideals a society may value; but also that this notwithstanding, considerations of justice are not all-sufficient, and do not, and should not, always override all other political ideals. (shrink)

NICE, the draft fertility guideline and dodging the big question: should fertility treatment be provided by the NHS?In August of this year the National Institute for Clinical Excellence made its draft guideline on fertility treatment available for consultation.1 As has been widely reported in the media the draft guideline recommends that the National Health Service should provide publicly funded fertility treatment in a consistent way across England and Wales. The guideline recommends that three cycles of IVF should be available when (...) “The woman is within the optimal range for in vitro fertilisation and there is an appropriately diagnosed cause of infertility of any duration, or unexplained infertility of at least three years’ duration .Those who need fertility treatment will celebrate the guideline, as will many fertility clinics. The guideline does not, however, address key questions that will be obvious to many. Is fertility treatment the kind of thing that ought to be available on the NHS? Will the inevitable increase in demand mean that resources are directed away from other services? Is fertility treatment really the same kind of intervention as heart or hip replacement surgery?My view is that there are good reasons for doing what we can to help people access fertility services. Most of us will start a family and for those of us who do it is probably the most important of all of our life projects. Given that social status and wealth can be significant obstacles to many of the things that people would like to do with their lives, the fact that most of us are able to pursue this important life project is good from an egalitarian …. (shrink)

This article demonstrates the benefit of studying a classical version of chromodynamics in order to better understand color charge in quantum chromodynamics. Standard presentations of the conservation and confinement of color charge serve to obscure the Lie-algebra-valued character of the conserved Noether charge. This article shows how we can remove these obscuring factors by studying color charge from the vantage point of classical chromodynamics. This key example of color charge illustrates the larger methodological benefit of this classical vantage point: interpreting (...) classical gauge theories helps to delineate the uniquely quantum features of quantum field theories. (shrink)

This work introduces the English-speaking reader to the theoretical foundations of Kng's popular works; an indispensable prolegomena for every future Christology.

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

This is the first of two volumes of essays in commemoration of Alan Turing, whose pioneering work in the theory of artificial intelligence and computer science continues to be widely discussed today. A group of prominent academics from a wide range of disciplines focus on three questions famously raised by Turing: What, if any, are the limits on machine `thinking'? Could a machine be genuinely intelligent? Might we ourselves be biological machines, whose thought consists essentially in nothing more than the (...) interaction of neurons according to strictly determined rules? The discussion of these fascinating issues is accessible to non-specialists and stimulating for all readers. (shrink)

Many of the original Saturday Night Live (SNL) cast and writers believed that cocaine was non‐addictive and that it was a logical drug to use to sustain the long hours of intense preparation necessary for a weekly live show. It's no secret that drugs and alcohol have been fuel for some SNL cast members. In the early days, the culture and writing of SNL were fueled by drugs, particularly cocaine and marijuana. So John Belushi's drug use was not at all (...) unique, and it justified his belief that people in the entertainment business needed to do drugs to cope with pressure and stress. Sadly, though, John and Chris Farley both lost their lives to overdoses at the young age of 33. Although Stuart Smalley pokes fun at the Pollyanna tone of recovery gurus, Al Franken himself has been a great advocate for the kind of twelve‐step programs that Chris Farley succeeded with for a time. (shrink)

The problem with which I wish to deal in this paper is the problem of singular reasons in the humanities, whether they exist, or rather, whether they can exist: for it would seem that the word “reason” carried with it some idea of generality, so that the phrase “singular reason” was a contradiction in terms, a specification which could never be fulfilled. But humanists are always sensing the singularity of their studies: and the philosopher wondering about the nature of humane (...) thinking either must conclude that it is really only inadequate science, its singularity being the mark of the fact that we never really have an adequate basis for any of our generalizations, an unfortunate reminder that the whole structure is built on the shakiest of inductive foundations; or , if he is unwilling to allow that humanists are just bad, or at least amateur, scientists, he is tempted to vindicate the rationality of their reasoning by inventing a special faculty of particular ratiocination which is able to perceive particular truths—the intuition of the moralists or the insight of the Collingwoodian mode. (shrink)

Janet Radcliffe Richards, J. R. Lucas; Discrimination, Proceedings of the Aristotelian Society, Volume 86, Issue 1, 1 June 1986, Pages 307–324, https://doi.org/.